People's way to immortality
And they said, “Come, let us build ourselves a city, and a tower whose top is in the heavens; let us make a name for ourselves, lest we be scattered abroad over the face of the whole earth.” - Genesis 11:4
For you have said in your heart:
‘ I will ascend into heaven,
I will exalt my throne above the stars of God;
I will also sit on the mount of the congregation
On the farthest sides of the north;
14 I will ascend above the heights of the clouds,
I will be like the Most High.’ - Isaiah 14:13-14
Mutant genes 'key to long life'
There is a clear link between living to 100 and inheriting a hyperactive version of an enzyme that prevents cells from ageing, researchers say.
Scientists from the Albert Einstein College of Medicine in the US say centenarian Ashkenazi Jews have this mutant gene.
They found that 86 very old people and their children had higher levels of telomerase which protects the DNA.
They say it may be possible to produce drugs that stimulate the enzyme.
There may be a downside to the plan of boosting the repair processes of DNA because giving the cells more chances to divide may increase the chances of damaging mutations developing and causing cancer. Professor Tim Spector, King's College
Writing in the Proceedings of the National Academy of Sciences, the team say they studied the Ashkenazi Jewish community because they are closely related so it is easier to identify disease causing genetic differences.
They took blood samples from 86 very old, but generally healthy, people with an average age of 97; 175 of their offspring; and 93 other people who were the offspring of parents who had lived a normal lifespan and could therefore make up a control group, with which the results could be compared.
Role of telomeres
Telomeres are relatively short sections of specialized DNA that sit at the ends of all our chromosomes.
They have been compared to the plastic tips at the ends of shoelaces that prevent the laces from unravelling.
Each time a cell divides, its telomeres shorten and the cell becomes more susceptible to dying.
The importance of telomeres was recognised last month when three scientists received the 2009 Nobel Prize in Physiology and Medicine for determining the structure of telomeres and discovering how they protect chromosomes from degrading.
Telomerase can repair the telomeres, preventing them from shrinking.
'Strongly heritable'
The team at Einstein found that the centenarians and their offspring had higher levels of telomerase and significantly longer telomeres than the unrelated people in the control group and that the trait was strongly heritable.
The scientists had previously shown that individuals in Ashkenazi families with exceptional longevity have generally been spared major age-related diseases, like heart disease and diabetes.
The centenarians in this study had a lower average body mass index than the controls and higher levels of good (HDL) cholesterol.
Yousin Suh, associate professor of medicine and genetics at Einstein and a lead author on the paper, said: "Our findings suggest that telomere length and variants of telomerase genes combine to help people live very long lives, perhaps by protecting them from the diseases of old age.
"We're now trying to understand the mechanism by which these genetic variants of telomerase maintain telomere length in centenarians.
"It may be possible to develop drugs that mimic the telomerase that our centenarians have been blessed with."
'Downside'
Professor Tim Spector, from King's College London, who has been researching telomeres and ageing, said it was an interesting finding but it may not apply to other populations and further research was needed.
He said: "There may be a downside to the plan of boosting the repair processes of DNA because giving the cells more chances to divide may increase the chances of damaging mutations developing and causing cancer.
"Most scientists agree that there is evidence that people with long telomeres have less age-related diseases and this study does suggest that could be one reason why they are living longer." [www.bbc.co.uk]
God's way to immortality
Whoever loves his life loses it, and whoever hates his life in this world will keep it for eternal life. - John 12:25
Whoever believes in the Son has eternal life; whoever does not obey the Son shall not see life, but the wrath of God remains on him. - John 3:36
But now that you have been set free from sin and have become slaves of God, the fruit you get leads to sanctification and its end, eternal life. - Romans 6:22
You search the Scriptures because you think that in them you have eternal life; and it is they that bear witness about me, 40yet you refuse to come to me that you may have life. - John 5:39-40
For as the Father raises the dead and gives life to them, even so the Son gives life to whom He will - John 5:21
Truly, truly, I say to you, whoever hears my word and believes him who sent me has eternal life. He does not come into judgment, but has passed from death to life.
"Truly, truly, I say to you, an hour is coming, and is now here, when the dead will hear the voice of the Son of God, and those who hear will live. For as the Father has life in himself, so he has granted the Son also to have life in himself. - John 5:24-26
And behold, a lawyer stood up to put him to the test, saying, "Teacher, what shall I do to inherit eternal life?" He said to him, "What is written in the Law? How do you read it?"And he answered, "You shall love the Lord your God with all your heart and with all your soul and with all your strength and with all your mind, and your neighbor as yourself." And he said to him, "You have answered correctly; do this, and you will live. - Luke 10:25-28
Whoever feeds on my flesh and drinks my blood has eternal life, and I will raise him up on the last day. - John 6:54
For the one who sows to his own flesh will from the flesh reap corruption, but the one who sows to the Spirit will from the Spirit reap eternal life. - Galatians 6:8
But whoever drinks of the water that I will give him will never be thirsty again. The water that I will give him will become in him a spring of water welling up to eternal life." - John 4:14
For God so loved the world, that he gave his only Son, that whoever believes in him should not perish but have eternal life. - John 3:16, etc.
‘ I will ascend into heaven,
I will exalt my throne above the stars of God;
I will also sit on the mount of the congregation
On the farthest sides of the north;
14 I will ascend above the heights of the clouds,
I will be like the Most High.’ - Isaiah 14:13-14
Mutant genes 'key to long life'
There is a clear link between living to 100 and inheriting a hyperactive version of an enzyme that prevents cells from ageing, researchers say.
Scientists from the Albert Einstein College of Medicine in the US say centenarian Ashkenazi Jews have this mutant gene.
They found that 86 very old people and their children had higher levels of telomerase which protects the DNA.
They say it may be possible to produce drugs that stimulate the enzyme.
There may be a downside to the plan of boosting the repair processes of DNA because giving the cells more chances to divide may increase the chances of damaging mutations developing and causing cancer. Professor Tim Spector, King's College
Writing in the Proceedings of the National Academy of Sciences, the team say they studied the Ashkenazi Jewish community because they are closely related so it is easier to identify disease causing genetic differences.
They took blood samples from 86 very old, but generally healthy, people with an average age of 97; 175 of their offspring; and 93 other people who were the offspring of parents who had lived a normal lifespan and could therefore make up a control group, with which the results could be compared.
Role of telomeres
Telomeres are relatively short sections of specialized DNA that sit at the ends of all our chromosomes.
They have been compared to the plastic tips at the ends of shoelaces that prevent the laces from unravelling.
Each time a cell divides, its telomeres shorten and the cell becomes more susceptible to dying.
The importance of telomeres was recognised last month when three scientists received the 2009 Nobel Prize in Physiology and Medicine for determining the structure of telomeres and discovering how they protect chromosomes from degrading.
Telomerase can repair the telomeres, preventing them from shrinking.
'Strongly heritable'
The team at Einstein found that the centenarians and their offspring had higher levels of telomerase and significantly longer telomeres than the unrelated people in the control group and that the trait was strongly heritable.
The scientists had previously shown that individuals in Ashkenazi families with exceptional longevity have generally been spared major age-related diseases, like heart disease and diabetes.
The centenarians in this study had a lower average body mass index than the controls and higher levels of good (HDL) cholesterol.
Yousin Suh, associate professor of medicine and genetics at Einstein and a lead author on the paper, said: "Our findings suggest that telomere length and variants of telomerase genes combine to help people live very long lives, perhaps by protecting them from the diseases of old age.
"We're now trying to understand the mechanism by which these genetic variants of telomerase maintain telomere length in centenarians.
"It may be possible to develop drugs that mimic the telomerase that our centenarians have been blessed with."
'Downside'
Professor Tim Spector, from King's College London, who has been researching telomeres and ageing, said it was an interesting finding but it may not apply to other populations and further research was needed.
He said: "There may be a downside to the plan of boosting the repair processes of DNA because giving the cells more chances to divide may increase the chances of damaging mutations developing and causing cancer.
"Most scientists agree that there is evidence that people with long telomeres have less age-related diseases and this study does suggest that could be one reason why they are living longer." [www.bbc.co.uk]
God's way to immortality
Whoever loves his life loses it, and whoever hates his life in this world will keep it for eternal life. - John 12:25
Whoever believes in the Son has eternal life; whoever does not obey the Son shall not see life, but the wrath of God remains on him. - John 3:36
But now that you have been set free from sin and have become slaves of God, the fruit you get leads to sanctification and its end, eternal life. - Romans 6:22
You search the Scriptures because you think that in them you have eternal life; and it is they that bear witness about me, 40yet you refuse to come to me that you may have life. - John 5:39-40
For as the Father raises the dead and gives life to them, even so the Son gives life to whom He will - John 5:21
Truly, truly, I say to you, whoever hears my word and believes him who sent me has eternal life. He does not come into judgment, but has passed from death to life.
"Truly, truly, I say to you, an hour is coming, and is now here, when the dead will hear the voice of the Son of God, and those who hear will live. For as the Father has life in himself, so he has granted the Son also to have life in himself. - John 5:24-26
And behold, a lawyer stood up to put him to the test, saying, "Teacher, what shall I do to inherit eternal life?" He said to him, "What is written in the Law? How do you read it?"And he answered, "You shall love the Lord your God with all your heart and with all your soul and with all your strength and with all your mind, and your neighbor as yourself." And he said to him, "You have answered correctly; do this, and you will live. - Luke 10:25-28
Whoever feeds on my flesh and drinks my blood has eternal life, and I will raise him up on the last day. - John 6:54
For the one who sows to his own flesh will from the flesh reap corruption, but the one who sows to the Spirit will from the Spirit reap eternal life. - Galatians 6:8
But whoever drinks of the water that I will give him will never be thirsty again. The water that I will give him will become in him a spring of water welling up to eternal life." - John 4:14
For God so loved the world, that he gave his only Son, that whoever believes in him should not perish but have eternal life. - John 3:16, etc.
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